Medieval and Renaissance humanist political discourse and Machiavelli -- Machiavelli and Spanish imperialist discourse in the sixteenth century -- Machiavelli and the foundations of the Spanish reason-of-state tradition : Giovanni Botero and Pedro de Ribadeneyra -- Machiavellian discourse in the Hispanic Baroque reason-of-state tradition -- Juan Pablo Mártir Rizo's rereading of the Prince -- Conclusion.

In his own lifetime Confucius never attained real power and he died feeling that his life had been a failure; yet his teaching came to dominate the political and ritual life of China for thousands of years and to inspire many thinkers in the outside world. Howard Smith describes China in the sixth century B.C. and shows how its history of internal conflict, together with the cult of ancestor worship, gave rise to Confucius' central doctrines of order and 'piety'. (...) He relates how a few disciples kept this teaching alive after Confucius' death and how it came finally to be accepted throughout the huge Chinese empire as the basis for political, educational and ceremonial life. He describes also how Confucianism was slowly changed by the rival philosophies and religions with which it had to compete. This book is therefore not only a history of one of the world's greatest systems of belief but also a study of how such a system both creates and is created by the society in which it exists. -- From publisher's description. (shrink)

Some scientists suggest that it might be possible to reflect a portion of incoming sunlight back into space to reduce climate change and its impacts. Others argue that such solar radiation management (SRM) geoengineering is inherently incompatible with democracy. In this article, we reject this incompatibility argument. First, we counterargue that technologies such as SRM lack innate political characteristics and predetermined social effects, and that democracy need not be deliberative to serve as a standard for governance. We then rebut each (...) of the argument’s core claims, countering that (1) democratic institutions are sufficiently resilient to manage SRM, (2) opting out of governance decisions is not a fundamental democratic right, (3) SRM may not require an undue degree of technocracy, and (4) its implementation may not concentrate power and promote authoritarianism. Although we reject the incompatibility argument, we do not argue that SRM is necessarily, or even likely to be, democratic in practice. (shrink)

Interviews focusing on the last century take a look at history from the standpoint of the ordinary people of the country.

‘‘Undone science’’ refers to areas of research that are left unfunded, incomplete, or generally ignored but that social movements or civil society organizations often identify as worthy of more research. This study mobilizes four recent studies to further elaborate the concept of undone science as it relates to the political construction of research agendas. Using these cases, we develop the argument that undone science is part of a broader politics of knowledge, wherein multiple and competing groups struggle over the construction (...) and implementation of alternative research agendas. Overall, the study demonstrates the analytic potential of the concept of undone science to deepen understanding of the systematic nonproduction of knowledge in the institutional matrix of state, industry, and social movements that is characteristic of recent calls for a ‘‘new political sociology of science.’’. (shrink)

Dramatic events involving dangerous microbes often focus attention on isolation and quarantine as policy instruments. The incident in May-June 2007 involving Andrew Speaker and drug-resistant tuberculosis joins other communicable disease crises that have forced contemplation or actual application of quarantine powers. Implementation of quarantine powers, which encompasses authority for both isolation and quarantine actions, is important not only for the handling of a specific event but also because the use of such authority provides a window on broader issues of public (...) health and the legal rules, ethical principles, and governance systems that support it. Debates about quarantine powers reflect political and social attitudes about public health that often tell us more about this policy endeavor than acts of isolation and quarantine themselves. (shrink)

Psychologists have often been criticized for their reluctance to engage with history, so it is interesting to find that historical accounts play an important role in the recovered memory/false memory syndrome debate. Using techniques of rhetorical and discursive analysis, we examined accounts of the historical origins of repression and of battlefield trauma in popular texts. The flexible and selective nature of these accounts was highlighted, and was discussed in terms of the rhetorical practice of ontological gerrymandering. Also, the employment of (...) discursive practices similar to Gilbert and Mulkay's (1984) `empiricist' and `contingent' repertoires was noted. We also comment upon how different understandings of the nature of history (as linear, cyclical, or geographical) were rhetorically employed by participants, and suggest that historical contexts are constructed for rhetorical effect. (shrink)

Spermatogenesis is an elaborate process involving both cell division and differentiation, and cell‐cell interactions. Defects in any of these processes can result in infertility, and in some cases these can be genetic in cause. Mapping experiments have defined at least three regions of the human Y chromosome that are required for normal spermatogenesis. Two of these contain the genes encoding the RNA binding proteins RBM and DAZ, suggesting that the control of RNA metabolism is likely to be an important control (...) point for human spermatogenesis. A similar analysis in mice has shown that at least two regions of the mouse Y chromosome are essential for spermatogenesis. Both genetic and reverse genetic approaches have been used to identify mouse autosomal genes required for spermatogenesis. These studies have shown that genes in a number of different pathways are essential for normal spermatogenesis, and also provide putative models of human infertility. (shrink)

A Dedekind-finite set is said to be divisible by a natural number n if it can be partitioned into pieces of size n. We study several aspects of this notion, as well as the stronger notion of being partitionable into n pieces of equal size. Among our results are that the divisors of a Dedekind-finite set can consistently be any set of natural numbers, that a Dedekind-finite power of 2 cannot be divisible by 3, and that a Dedekind-finite set can (...) be congruent modulo 3, to all of 0, 1, and 2 simultaneously. (shrink)

Interaction of ligands such as epidermal growth factor and interferon‐γ with the extracellular domains of their plasma membrane receptors results in internalization followed by translocation into the nucleus of the ligand and/or receptor. There has been reluctance, however, to ascribe signaling importance to this, the focus instead being on second messenger pathways, including mobilization of kinases and inducible transcription factors (TFs). The latter, however, fails to explain the fact that so many ligands stimulate the same second messenger cascades/TFs, and yet (...) show distinct gene activation profiles. This is particularly apt in the case of the seven STAT TFs that are held to be the mediators of the distinct cellular functions of over 60 ligands. The current review focuses on five representative nuclear localizing ligands for which there is documentation of translocation into the cytosol and nucleus through well‐characterized pathways, in addition to a role in gene activation by ligand/receptor in the nucleus. BioEssays 26:993‐1004, 2004. © 2004 Wiley Periodicals, Inc. (shrink)

We develop a logical modelling approach to describe evolvable computational systems. In this account, evolvable systems are built hierarchically from components where each component may have an associated supervisory process. The supervisor's purpose is to monitor and possibly change its associated component. Evolutionary change may be determined purely internally from observations made by the supervisor or may be in response to external change. Supervisory processes may be present at any level in the component hierarchy allowing us to use evolutionary behaviour (...) as an integral part of system design. We model such systems in a revision-based first-order logical framework in which supervisors are modelled as theories which are at a logical meta-level to the theories of their components. This enables evolutionary change of the component to be induced by revision-based changes of the supervisor at the meta-level. In this way, the intervention required in evolutionary change is modelled purely logically. The hierarchical component-based structure is fairly intricate so we present the basic ideas firstly in a simple setting, the well-known blocks world, before introducing tree-based structures to represent component hierarchies. We also introduce some techniques for establishing the behaviour of evolvable systems specified in this logical framework. The ideas and concepts are driven by example throughout. We conclude with a more substantial example, that of a simple model of an evolvable system of automated bank teller machines. (shrink)

Drawing on 171 in-depth interviews with physicists at universities in the United States and the UK, this study examines the narratives of 48 physicists to explain the concept of ethical ambiguity: the border where legitimate and illegitimate conduct is blurred. Researchers generally assume that scientists agree on what constitutes both egregious and more routine forms of misconduct in science. The results of this study show that scientists perceive many scenarios as ethically gray, rather than black and white. Three orientations to (...) ethical ambiguity are considered—altruism, inconsequential outcomes, and preserving the status quo—that allow possibly questionable behavior to persist unchallenged. Each discursive strategy is rationalized as promoting the collective interest of science rather than addressing what is ethically correct or incorrect. The results of this study suggest that ethics training in science should focus not only on fabrication, falsification, and plagiarism and more routine forms of misconduct, but also on strategies for resolving ethically ambiguous scenarios where appropriate action may not be clear. (shrink)

Machine generated contents note: -- Preface -- Acknowledgements -- Notes on Contributors -- PART I: COMPLEXITY IN ANIMAL MINDS -- Introduction: M.McGonigle-Chalmers -- Relational and Absolute Discrimination Learning by Squirrel Monkeys: Establishing a Common Ground with Human Cognition; B.T.Jones -- Serial List Retention by Non-Human Primates: Complexity and Cognitive Continuity; F.R.Treichler -- The Use of Spatial Structure in Working Memory: A Comparative Standpoint; C.De Lillo -- The Emergence of Linear Sequencing in Children: A Continuity Account and a Formal Model; M.McGonigle-Chalmers&I.Kusel (...) -- Sensitivity to Quantity: What Counts Across Species?; S.T.Boysen&A.M.Yocom -- PART II: COMPLEXITY IN ROBOTS -- Editorial Introduction; D.McFarland -- Towards Cognitive Robotics: Robotics, Biology and Developmental Psychology; M.Lee, U.Nehmzow&M.Rodriguez -- Structuring Intelligence: The Role of Hierarchy, Modularity and Learning in Generating Intelligent Behaviour; J.J.Bryson -- Epistemology, Access, and Computational Models; G.Luger -- Reasoning About Representations in Autonomous Systems: What P´Olya and Lakatos Have To Say; A.Bundy -- PART III: LANGUAGE, EVOLUTION AND THE COMPLEX MIND -- Editorial Introduction; K.Stenning -- How to Qualify for a Cognitive Upgrade: Executive Control, Glass Ceilings, and the Limits of Simian Success; A.Clark -- Private Codes and Public Structures; C.Allen -- The Emergence of Complex Language; W.Hinzen -- Language Evolution: Enlarging the Picture; K.Stenning&M.Van Lambalgen -- Epilogue: Reminiscences of Brendan McGonigle -- Index. (shrink)

Background: Current practice frequently fails to provide care consistent with the preferences of decisionally-incapacitated patients. It also imposes significant emotional burden on their surrogates. Algorithmic-based patient preference predictors (PPPs) have been proposed as a possible way to address these two concerns. While previous research found that patients strongly support the use of PPPs, the views of surrogates are unknown. The present study thus assessed the views of experienced surrogates regarding the possible use of PPPs as a means to help make (...) treatment decisions for decisionally-incapacitated patients. -/- Methods: This qualitative study used semi-structured interviews to determine the views of experienced surrogates [n=26] who were identified from two academic medical centers and two community hospitals. The primary outcomes were respondents’ overall level of support for the idea of using PPPs and the themes related to their views on how a PPP should be used, if at all, in practice. -/- Results: Overall, 21 participants supported the idea of using PPPs. The remaining five indicated that they would not use a PPP because they made decisions based on the patient’s best interests, not based on substituted judgment. Major themes which emerged were that surrogates, not the patient’s preferences, should determine how treatment decisions are made, and concern that PPPs might be used to deny expensive care or be biased against minority groups. -/- Conclusions: Surrogates, like patients, strongly support the idea of using PPPs to help make treatment decisions for decisionally-incapacitated patients. These findings provide support for developing a PPP and assessing it in practice. At the same time, patients and surrogates disagree over whose preferences should determine how treatment decisions are made, including whether to use a PPP. These findings reveal a fundamental disagreement regarding the guiding principles for surrogate decision-making. Future research is needed to assess this disagreement and consider ways to address it. (shrink)

Entrepreneurs of contested commodities often face stakeholders engaged in market excluding boundary work driven by ethical considerations. For example, the conversion of academic scientific knowledge into technologies that can be owned and sold is a growing global trend and key stakeholders have different ethical responses to this contested commodity. Commercialization of science can be viewed as a good thing because people believe it bolsters economic growth and broadly benefits society. Others view it as bad because they believe it discourages basic (...) research that ought to be freely shared without concern for profit. Taking a descriptive sociological approach, we posit that the stance of a religious tradition toward capitalism will help shape individual scientists’ views on science commercialization and test whether the religious tradition of scientists correlates with their attitude toward the commercialization of science. To maximize variance on the religious tradition dimension, we analyze pooled data from a cross-national survey of university biologists and physicists encompassing France, Hong Kong, India, Italy, Taiwan, Turkey, UK and the USA. We indeed find religious tradition differences. Hindus and scientists with no religious tradition are more likely to agree that commercialization of science “harms a university’s commitment to knowledge production” than Protestants. We end with a discussion on business ethics and the moral limits of the market as well as implications for entrepreneurs of contested commodities. (shrink)

In this astonishingly rich volume, experts in ethics, epistemology, philosophy of mind, political theory, aesthetics, history, critical theory, and hermeneutics bring to light the best philosophical scholarship on what is arguably Nietzsche's most rewarding but most challenging text. Including essays that were commissioned specifically for the volume as well as essays revised and edited by their authors, this collection showcases definitive works that have shaped Nietzsche studies alongside new works of interest to students and experts alike. A lengthy introduction, annotated (...) bibliography, and index make this an extremely useful guide for the classroom and advanced research. (shrink)